Nanotechnology is a revolutionary field focused on manipulating matter at the atomic and molecular scale. With applications across health, agriculture, and water purification, nanotechnology offers unique properties that can address critical challenges such as health disparities and food security. A systematic literature review was conducted, analysing articles and case studies relevant to nanotechnology in Zimbabwe, incorporating both local and international perspectives. The overall goal of this study was to collate a scoping review of nanotechnology with particular focus on content related to application opportunities in Zimbabwe. Key initiatives identified include the development of smart nano-filters for water purification and the application of nanomaterials in medical treatments. These innovations demonstrate significant potential to enhance public health outcomes and improve access to clean water, particularly in underserved areas. Despite its promise, barriers such as infrastructural deficits, funding limitations, and a lack of expertise impede the widespread adoption of nanotechnology. Strategic investments and collaborative efforts are essential to overcome these challenges and fully leverage nanotechnology's benefits. Advancing nanotechnology in Zimbabwe is vital for addressing pressing health and environmental issues. By fostering a supportive ecosystem for research and development, Zimbabwe can harness nanotechnology to drive sustainable development and improve the quality of life for its citizens.